Studies on Retinal and Choroidal Disorders examines the role that oxidative and
nitrosative stress plays in the complex physiology and pathophysiology of the
retina and choroid. Both the basic science researcher and the clinical
practitioner can use this book as a guide to the current understanding of
retinal and choroidal cellular mechanisms involved in aging and disease.
Beginning with a review of oxidative stress and inflammation in the
pathoetiology of AMD and a review of the complement system in the retina, the
book then takes a detailed look at oxidative stress in lipid metabolism and
oxidized lipoproteins in the retina. It examines the anti-apoptotic activity
of a-crystallins in the presence of glutathione, oxidative stress in the
mitochondria and endoplasmic reticulum, the role of iron in retinal disease,
the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and
Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look
at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed
examination of the systemic changes in AMD is followed by a discussion of
cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss
progenitor cells in the cause and treatment of retinal diseases including AMD
and diabetic retinopathy. Natural compounds in the prevention and treatment of
retinal diseases are exhaustively presented, followed by a chapter on serotonin
5-HT1A receptor agonists in oxidative stress of the retina. The current anti-
VEGF treatment strategies of neovascular AMD are then given. The volume
continues with a detailed look at nitric oxide and inducible nitric oxide
synthase in retinal vascular disease, an explanation of an in vivo technique of
studying the effect of lipid hydroperoxides on circulating leucocytes in the
retina, an excellent review of oxidative stress in retinopathy of prematurity,
and a look at VEGF induced oxidative stress in the retinal ganglion cell. The
book ends with a detail examination of the role of carotenoids in retinal
health and disease. These 31 chapters summarize what is known about oxidative
stress in retinal and choroidal disorders. All those involved with degenerative
diseases of the eye will find Studies on Retinal and Choroidal Disorders to be
illuminating and comprehensive.
