Combinatorial chemistry and molecular diversity approaches to scientific and
novel product R & D have exploded in the 1990s. For example, in the preparation
of drug candidates, the automated, permutational, and combinatorial use of
chemical building blocks now allows the generation and screening of
unprecedented numbers of compounds. Drug discovery - better, faster, cheaper?
Indeed more compounds have been made and screened in the 1990s than in the last
hundred years of pharmaceutical research. The second volume in this series
includes contributions on methods, solid phases, purification, analysis,
carbohydrates, patent strategies and tactics, diversity profiling and
combinatorial series design, and finishes with a survey of chemical libraries
yielding biologically active agents and a compendium of solid phase chemistry
publications. Each contribution is prepared by a recognized expert resulting in
a high quality account of the recent advances in the field.
